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Selenium nanoparticles stimulate osteoblast differentiation via BMP-2/MAPKs/β-catenin pathway in diabetic osteoporosis.
- Source :
-
Nanomedicine (London, England) [Nanomedicine (Lond)] 2022 Apr; Vol. 17 (9), pp. 607-625. Date of Electronic Publication: 2022 Apr 25. - Publication Year :
- 2022
-
Abstract
- Aim: To evaluate whether selenium nanoparticles (SeNPs) can stimulate bone formation and inhibit the bone loss involved in hyperglycemia-induced osteoporosis. Methods: Rat osteoblastic UMR-106 cells were used for in vitro studies and female Sprague-Dawley rats were used for type 2 diabetes-associated osteoporosis in vivo study. Results: In vitro studies show that SeNPs promote osteoblast differentiation via modulating alkaline phosphatase (ALP) activity, and promoting calcium nodule formation and collagen content. The authors also provide evidence regarding the involvement of the BMP-2/MAPKs/β-catenin pathway in preventing diabetic osteoporosis. Further, in vivo and ex vivo studies suggested that SeNPs can preserve mechanical and microstructural properties of bone. Conclusion: To the best of our knowledge, this study provides the first evidence regarding the therapeutic benefits of SeNPs in preventing diabetes-associated bone fragility.
- Subjects :
- Animals
Female
Osteoblasts drug effects
Osteoblasts metabolism
Osteogenesis drug effects
Rats
Rats, Sprague-Dawley
Bone Morphogenetic Protein 2 metabolism
Cell Differentiation drug effects
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 metabolism
Diabetes Mellitus, Type 2 pathology
MAP Kinase Signaling System drug effects
Nanoparticles administration & dosage
Nanoparticles chemistry
Osteoporosis complications
Osteoporosis drug therapy
Osteoporosis metabolism
Osteoporosis pathology
Selenium chemistry
Selenium pharmacology
beta Catenin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1748-6963
- Volume :
- 17
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nanomedicine (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 35465693
- Full Text :
- https://doi.org/10.2217/nnm-2021-0401