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Limited Neutralization of Omicron by Antibodies from the BNT162b2 Vaccination against SARS-CoV-2.
- Source :
-
Research square [Res Sq] 2022 Apr 14. Date of Electronic Publication: 2022 Apr 14. - Publication Year :
- 2022
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Abstract
- Since early December 2021, the omicron variant has posed additional challenges to the world-wide management of the SARS-CoV-2 pandemic. Immune evasion is a key factor for its increased transmissibility. While serological studies have measured levels of neutralizing antibodies in response to vaccines, our understanding of the humoral immune response to omicron on a single-antibody level is limited. Here, we characterize a set of BNT162b2 vaccine-derived antibodies for neutralization of omicron pseudovirus. We show that approximately 50% of neutralizing anti-RBD antibodies cross-neutralize omicron, albeit with lower potency than the original Wuhan-Hu1 strain. All investigated neutralizing anti-S2 antibodies cross-neutralize omicron, however all of them are less potent than anti-RBD antibodies. While additional booster immunizations of the current vaccine generate increased antibody levels and better protection, we anticipate that the second generation of vaccines will yield more high-affinity antibodies against omicron.<br />Competing Interests: WHR is a Founder, member of the Board of Directors, and consultant to Atreca, Inc. The remaining authors declare no competing interests.
Details
- Language :
- English
- Database :
- MEDLINE
- Journal :
- Research square
- Accession number :
- 35441169
- Full Text :
- https://doi.org/10.21203/rs.3.rs-1518378/v1