Automated Synthesis of 18 F-BCPP-EF {2- tert -Butyl-4-Chloro-5-{6-[2-(2[ 18 F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2 H -Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson's Disease.

Mitochondrial complex I (MC-I) is an essential component of brain bioenergetics and can be quantified and studied using positron emission tomography (PET). A specific high affinity ¹⁸ F radiotracer for MC-I enables monitoring of neurodegenerative disease progression and pathology via PET imaging. To facilitate clinical research studies tracking MC-I activity in Parkinson's disease and other neurodegenerative diseases, a fully automated synthesis of the recently described 2 -tert -butyl-4-chloro-5-{6-[2-(2[ ¹⁸ F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2 H -pyridazin-3-one ([ ¹⁸ F] BCPP-EF, [ ¹⁸ F]1 ) was developed. We report the first automated synthesis [ ¹⁸ F]BCPP-EF using a green radiochemistry approach. The radiotracer was synthesized with good radiochemical yield, excellent radiochemical purity, and high molar activity.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Kaur, Brooks, Liddell, Henderson, Hockley, Bohnen, Albin and Scott.)