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Plasma Endogenous Endotoxin Core Antibody Response to Exercise in Endurance Athletes.
- Source :
-
International journal of sports medicine [Int J Sports Med] 2022 Nov; Vol. 43 (12), pp. 1023-1032. Date of Electronic Publication: 2022 Apr 14. - Publication Year :
- 2022
-
Abstract
- The study aimed to investigate the impact of laboratory-controlled exertional and exertional-heat stress on concentrations of plasma endogenous endotoxin core antibody (EndoCAb). Forty-four (males n= 26 and females n= 18) endurance trained ( V̇ O <subscript>2max</subscript> 56.8min/kg/min) participants completed either: P1-2h high intensity interval running in 23°C ambient temperature (T <subscript>amb</subscript> ), P2-2h running at 60% V̇ O <subscript>2max</subscript> in 35°C T <subscript>amb</subscript> , or P3-3h running at 60% V̇ O <subscript>2max</subscript> in 23°C T <subscript>amb</subscript> . Blood samples were collected pre- and post-exercise to determine plasma IgM, IgA, and IgG concentrations. Overall resting pre-exercise levels for plasma Ig were 173MMU/ml, 37AMU/ml, and 79GMU/ml, respectively. Plasma IgM concentration did not substantially change pre- to post-exercise in all protocols, and the magnitude of pre- to post-exercise change for IgM was not different between protocols (p=0.135). Plasma IgA and IgG increased pre- to post-exercise in P2 only (p=0.017 and p=0.016, respectively), but remained within normative range (35-250MU/ml). P2 resulted in greater disturbances to plasma IgA (p=0.058) and IgG (p=0.037), compared with P1 and P3. No substantial differences in pre-exercise and exercise-associated change was observed for EndoCAb between biological sexes. Exertional and exertional-heat stress resulted in modest disturbances to systemic EndoCAb responses, suggesting EndoCAb biomarkers presents a low sensitivity response to controlled-laboratory experimental designs within exercise gastroenterology.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
Details
- Language :
- English
- ISSN :
- 1439-3964
- Volume :
- 43
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of sports medicine
- Publication Type :
- Academic Journal
- Accession number :
- 35426092
- Full Text :
- https://doi.org/10.1055/a-1827-3124