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Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes.

Authors :
Begum Z
Sannabe H
Seki C
Okuyama Y
Kwon E
Uwai K
Tokiwa M
Tokiwa S
Takeshita M
Nakano H
Source :
RSC advances [RSC Adv] 2020 Dec 22; Vol. 11 (1), pp. 203-209. Date of Electronic Publication: 2020 Dec 22 (Print Publication: 2020).
Publication Year :
2020

Abstract

Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature.<br />Competing Interests: There are no conflicts to declare.<br /> (This journal is © The Royal Society of Chemistry.)

Details

Language :
English
ISSN :
2046-2069
Volume :
11
Issue :
1
Database :
MEDLINE
Journal :
RSC advances
Publication Type :
Academic Journal
Accession number :
35423042
Full Text :
https://doi.org/10.1039/d0ra09041g