Superior cervical ganglionectomy alters gut microbiota in rats.

Authors :: Zhang W
Li Y
Sun T
Li Z
Manyande A
Xu W
Feng M
Xiang H
Source :: American journal of translational research [Am J Transl Res] 2022 Mar 15; Vol. 14 (3), pp. 2037-2050. Date of Electronic Publication: 2022 Mar 15 (Print Publication: 2022).
Publication Year :: 2022
Abstract: The diversity and complexity of sympathetic function highlight the importance of fundamental research. Little is known about the interaction of superior cervical sympathetic ganglion (SCG) and gut microbiota. In this study, the engagement of the sympathetic ganglia with gut microbiota was investigated. Bilateral superior cervical ganglionectomy (SCGx) significantly altered the microbiota composition in rats 14 days post-surgery, and these microbiotas may participate in several biological pathways in the host, suggesting the vital role of the cervical sympathetic ganglion in regulating the microbiome-brain axis, and further confirming that the sympathetic nervous system (SNS) regulates the microbiome-brain axis.<br />Competing Interests: None.<br /> (AJTR Copyright © 2022.)

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