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SARS-CoV-2 Positivity in Early Infancy: A National Cohort From Saudi Arabia.

Authors :
Shaiba LA
Hadid A
Altirkawi K
Alnamnakani MA
Almutayliq AA
Alharbi AT
Hijazi AM
AlMoosa KM
AlSaud NF
Murshid RE
AlMuhanna WS
Aldawsari NA
Bin Hadyan MF
Almaghrabi R
Alsofayan YM
Alahmari AA
Almuzaini YS
Alamri FA
Khan AA
Shah PS
Source :
Frontiers in pediatrics [Front Pediatr] 2022 Mar 28; Vol. 10, pp. 849659. Date of Electronic Publication: 2022 Mar 28 (Print Publication: 2022).
Publication Year :
2022

Abstract

Background: Data on SARS-CoV-2 in infants ≤ 90 days are limited with conflicting reports regarding its presentation and outcomes.<br />Methods: We conducted an ambispective cohort study using prospectively collected Health Electronic Surveillance Network Database by the Ministry of Health, Saudi Arabia. Infants of ≤ 90 days of age who had a positive RT-PCR test for SARS-CoV-2 virus were included. Patients were divided in Early neonatal (0-6 days), late neonatal (7-27 days), and post- neonatal (28-90 days) groups and were compared for clinical characteristics and outcomes by contacting parents and collecting information retrospectively.<br />Results: Of 1,793 infants, 898 infants were included for analysis. Most infants in the early neonatal group had no features of infection (tested based on maternal positivity), whereas most infants in the late and post- neonatal groups were tested because of clinical features of infection. Fever and respiratory signs were the most common presenting feature in the late and post-neonatal groups. Hospitalization was higher in the early neonatal group (80%), compared to the two other groups. The overall mortality in the cohort was 1.6%.<br />Conclusion: SARS-CoV-2 infection in infants ≤ 90 days might not be as rare as previously reported. The clinical presentation varies based on age at positive RT-PCR result.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Shaiba, Hadid, Altirkawi, Alnamnakani, Almutayliq, Alharbi, Hijazi, AlMoosa, AlSaud, Murshid, AlMuhanna, Aldawsari, Bin Hadyan, Almaghrabi, Alsofayan, Alahmari, Almuzaini, Alamri, Khan and Shah.)

Details

Language :
English
ISSN :
2296-2360
Volume :
10
Database :
MEDLINE
Journal :
Frontiers in pediatrics
Publication Type :
Academic Journal
Accession number :
35419319
Full Text :
https://doi.org/10.3389/fped.2022.849659