Catalytic, Asymmetric Total Synthesis of (+)-α-, (+)-β-, (+)-γ-, and (-)-δ-Lycorane.

The first collectively asymmetric total synthesis of all members of lycorane, including (+)-α, (+)-β, (+)-γ, and (-)-δ, in a catalytic manner has been achieved. The cornerstone of this synthesis features an asymmetric, stereodivergent Ir/amine dual catalytic α-allylation of 2-phthalimidoacetaldehyde.