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Anti-Inflammatory and Analgesic Effects of Schisandra chinensis Leaf Extracts and Monosodium Iodoacetate-Induced Osteoarthritis in Rats and Acetic Acid-Induced Writhing in Mice.
- Source :
-
Nutrients [Nutrients] 2022 Mar 24; Vol. 14 (7). Date of Electronic Publication: 2022 Mar 24. - Publication Year :
- 2022
-
Abstract
- In this study, we aimed to determine the anti-inflammatory and antinociceptive activities of Schisandra chinensis leaf extracts (SCLE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, an acetic acid-induced mouse model of writhing, and a monosodium iodoacetate (MIA)-induced rat model of osteoarthritis (OA). In LPS-stimulated RAW264.7 cells, a 100 µg/mL dose of SCLE significantly reduced the production of nitric oxide (NO), interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and prostaglandin E2 (PGE2). Acetic acid-induced writhing responses in mice that quantitatively determine pain were significantly inhibited by SCLE treatment. In addition, SCLE significantly decreased the MIA-induced elevation in OA symptoms, the expression levels of pro-inflammatory mediators/cytokines and matrix metalloproteinases, and cartilage damage in the serum and joint tissues. Our data demonstrated that SCLE exerts anti-osteoarthritic effects by regulating inflammation and pain and can be a useful therapeutic candidate against OA.
- Subjects :
- Acetic Acid therapeutic use
Analgesics adverse effects
Animals
Anti-Inflammatory Agents adverse effects
Iodoacetic Acid toxicity
Lipopolysaccharides pharmacology
Mice
Pain chemically induced
Pain drug therapy
Plant Extracts adverse effects
Rats
Osteoarthritis chemically induced
Osteoarthritis drug therapy
Schisandra
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 14
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 35405969
- Full Text :
- https://doi.org/10.3390/nu14071356