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Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia.
- Source :
-
Acta tropica [Acta Trop] 2022 Jul; Vol. 231, pp. 106437. Date of Electronic Publication: 2022 Apr 08. - Publication Year :
- 2022
-
Abstract
- We assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminth (STH) infections and schistosomiasis in Lofa County, Liberia. The study started in 2012 and was interrupted in 2014 during the Ebola virus outbreak. Repeated cross-sectional surveys were conducted in individuals 5 years and older to measure infection markers. Wuchereria bancrofti antigenemia prevalences decreased from 12.5 to 1.2% (90% reduction) and from 13.6 to 4.2% (69% reduction) one year after three rounds of annual or five rounds of semiannual MDA, respectively. Mixed effects logistic regression models showed decreases in odds of antigenemia positivity were 91 and 74% at that time in the annual and semiannual treatment zones, respectively (p < 0.001). Semiannual MDA was slightly more effective for reducing Onchocerca volvulus microfiladermia prevalence and at follow-up 3 were 74% (from 14.4 to 3.7%) and 83% (from 23.6 to 4.5%) in the annual and semiannual treatment zones, respectively. Both treatment schedules had similar beneficial effects on hookworm prevalence. Thus, annual and semiannual MDA with ivermectin and albendazole had similar beneficial impacts on LF, onchocerciasis, and STH in this setting. In contrast, MDA with praziquantel had little impact on hyperendemic Schistosoma mansoni in the study area. Results from a long-term follow-up survey showed that improvements in infection parameters were sustained by routine annual MDA provided by the Liberian Ministry of Health after our study endpoint.<br /> (Copyright © 2022. Published by Elsevier B.V.)
- Subjects :
- Albendazole pharmacology
Albendazole therapeutic use
Animals
Cross-Sectional Studies
Humans
Ivermectin pharmacology
Ivermectin therapeutic use
Liberia epidemiology
Mass Drug Administration methods
Praziquantel pharmacology
Praziquantel therapeutic use
Prevalence
Soil
Wuchereria bancrofti
Elephantiasis, Filarial drug therapy
Elephantiasis, Filarial epidemiology
Helminthiasis drug therapy
Helminthiasis epidemiology
Onchocerciasis drug therapy
Onchocerciasis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6254
- Volume :
- 231
- Database :
- MEDLINE
- Journal :
- Acta tropica
- Publication Type :
- Academic Journal
- Accession number :
- 35405102
- Full Text :
- https://doi.org/10.1016/j.actatropica.2022.106437