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Predictive molecular pathology in metastatic thyroid cancer: the role of RET fusions.
- Source :
-
Expert review of endocrinology & metabolism [Expert Rev Endocrinol Metab] 2022 Mar; Vol. 17 (2), pp. 167-178. Date of Electronic Publication: 2022 Apr 11. - Publication Year :
- 2022
-
Abstract
- Background: Rearranged during transfection ( RET ) gene fusions are detected in 10-20% of thyroid cancer patients. Recently, RET fusion-positive metastatic thyroid cancers have attracted much attention owing to the FDA approval of two highly selective anti-RET tyrosine kinase inhibitors, namely, selpercatinib, and pralsetinib.<br />Areas Covered: This review summarizes the available evidence on the biological and predictive role of RET gene fusions in thyroid carcinoma patients and the latest screening assays currently used to detect these genomic alterations in histological and cytological specimens.<br />Expert Opinion: Management of advanced thyroid carcinoma has significantly evolved over the last decade thanks to the approval of three multikinase inhibitors, i.e. sorafenib, lenvatinib, cabozantinib, and of two selective RET-tyrosine inhibitors, i.e. selpercatinib and pralsetinib. In this setting, the detection of RET-fusions in advanced thyroid cancer specimens through the use of next-generation sequencing has become a commonly used strategy in clinical practice to select the best treatment options.
- Subjects :
- Gene Fusion
Humans
Pathology, Molecular
Protein Kinase Inhibitors pharmacology
Protein Kinase Inhibitors therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung genetics
Lung Neoplasms drug therapy
Lung Neoplasms genetics
Proto-Oncogene Proteins c-ret genetics
Proto-Oncogene Proteins c-ret therapeutic use
Thyroid Neoplasms drug therapy
Thyroid Neoplasms genetics
Thyroid Neoplasms secondary
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8417
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Expert review of endocrinology & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 35404189
- Full Text :
- https://doi.org/10.1080/17446651.2022.2060819