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Treatment of Focal and Segmental Glomerulosclerosis Secondary to High Altitude Polycythemia with Acetazolamide.
- Source :
-
High altitude medicine & biology [High Alt Med Biol] 2022 Sep; Vol. 23 (3), pp. 286-290. Date of Electronic Publication: 2022 Apr 08. - Publication Year :
- 2022
-
Abstract
- Vizcarra-Vizcarra, Cristhian A., Eduardo Chávez-Velázquez, Carmen Asato-Higa, and Abdías Hurtado-Aréstegui. Treatment of focal and segmental glomerulosclerosis secondary to high altitude polycythemia with acetazolamide. High Alt Med Biol . 23:286-290, 2022.-Focal segmental glomerulosclerosis (FSGS) is a morphological pattern, caused by glomerular injury and is the leading cause of nephrotic syndrome in adults. We present the case of a 59-year-old female patient, resident of a high-altitude city (3,824 m), who had polycythemia and nephrotic syndrome. A renal biopsy was performed, and the findings were compatible with FSGS. The patient received phlebotomy 500 ml three times, which reduced, partially, the hemoglobin concentration. However, she had refractory proteinuria, despite the use of enalapril and spironolactone. We observed that proteinuria worsened with the increase in hemoglobin levels. So, she was treated with acetazolamide 250 mg bid for 4 months, which reduced proteinuria and hemoglobin. During the coronavirus disease 2019 (COVID-19) pandemic, the patient did not take acetazolamide and again, she had an increase in hemoglobin and proteinuria levels. We conclude that acetazolamide may be an effective treatment in FSGS due to high altitude polycythemia.
- Subjects :
- Acetazolamide therapeutic use
Adult
Altitude
Female
Humans
Middle Aged
Proteinuria etiology
Altitude Sickness complications
Altitude Sickness drug therapy
COVID-19
Glomerulosclerosis, Focal Segmental complications
Glomerulosclerosis, Focal Segmental etiology
Nephrotic Syndrome complications
Nephrotic Syndrome pathology
Polycythemia complications
Polycythemia etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8682
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- High altitude medicine & biology
- Publication Type :
- Academic Journal
- Accession number :
- 35394893
- Full Text :
- https://doi.org/10.1089/ham.2021.0158