HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission.

Authors :: Koole JC
de la Court F
Welkers MR
Yap K
Stalenhoef JE
Jurriaans S
de Vries HJ
Op de Coul EL
Prins M
Hoornenborg E
Source :: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2022 Apr; Vol. 27 (14).
Publication Year :: 2022
Abstract: In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using event-driven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017-19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms.

Subjects :: Emtricitabine therapeutic use
Homosexuality, Male
Humans
Male
Medication Adherence
Netherlands epidemiology
Self Report
Tenofovir therapeutic use
Anti-HIV Agents therapeutic use
HIV Infections diagnosis
HIV Infections drug therapy
HIV Infections prevention & control
HIV-1 genetics
Pre-Exposure Prophylaxis
Sexual and Gender Minorities

Language :: English
ISSN :: 1560-7917
Volume :: 27
Issue :: 14
Database :: MEDLINE
Journal :: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Publication Type :: Academic Journal
Accession number :: 35393931
Full Text :: https://doi.org/10.2807/1560-7917.ES.2022.27.14.2200275

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