Scleredema with biopsy-confirmed cardiomyopathy: A case report.

Authors :: Nakatsuji M
Ishimaru N
Ohnishi J
Mizuki S
Kanzawa Y
Kawano K
Nakajima T
Kuroda M
Sano N
Kinami S
Source :: Journal of scleroderma and related disorders [J Scleroderma Relat Disord] 2021 Oct; Vol. 6 (3), pp. 311-315. Date of Electronic Publication: 2021 May 12.
Publication Year :: 2021
Abstract: Scleredema is a rare cutaneous mucinosis characterized by diffuse swelling and non-pitting induration. A 63-year-old man reported a 5-year history of skin thickening of the trunk and a 3-week history of dyspnea. Echocardiography revealed diffuse hypokinesis. Skin biopsies obtained from the waist showed thickened dermis with mucin. Myocardial biopsies showed alcian blue-stained tissue between the muscle fibers. The patient was referred to a dermatologist for phototherapy. Cardiomyopathy should be considered in patients with scleredema. Scleredema usually has a good prognosis; however, the mortality risk could be high when accompanied by cardiomyopathy.<br />Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.<br /> (© The Author(s) 2021.)