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The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism.
- Source :
-
Journal of the Endocrine Society [J Endocr Soc] 2022 Mar 04; Vol. 6 (5), pp. bvac034. Date of Electronic Publication: 2022 Mar 04 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Context: Blood lipid levels are linked to the risk of cardiovascular disease and regulated by genetic factors. A low-frequency polymorphism Arg82Cys (rs72836561) in the membrane protein nepmucin, encoded by CD300LG , is associated with lower fasting concentration of high-density lipoprotein cholesterol (HDLc) and higher fasting triglycerides. However, whether the variant is linked to postprandial lipids and glycemic status remains elusive.<br />Objective: Here, we augment the genetic effect of Arg82Cys on fasting plasma concentrations of HDL subclasses, postprandial lipemia after a standardized high-fat meal, and glycemic status to further untangle its role in HDL metabolism.<br />Methods: We elucidated fasting associations with HDL subclasses in a population-based cohort study (Oxford BioBank, OBB), including 4522 healthy men and women. We investigated fasting and postprandial consequences on HDL metabolism in recall-by-genotype (RbG) studies (fasting: 20 carrier/20 noncarrier; postprandial: 7 carrier/17 noncarrier), and shed light on the synergistic interaction with glycemic status.<br />Results: A lower fasting plasma concentration of cholesterol in large HDL particles was found in healthy male carriers of the Cys82 polymorphism compared to noncarriers, both in the OBB ( P = .004) and RbG studies ( P = .005). In addition, the Cys82 polymorphism was associated with low fasting plasma concentrations of ApoA1 ( P = .008) in the OBB cohort. On the contrary, we did not find differences in postprandial lipemia or 2-hour plasma glucose levels.<br />Conclusion: Taken together, our results indicate an association between the Arg82Cys variant and a lower concentration of HDL particles and HDLc, especially in larger HDL subclasses, suggesting a link between nepmucin and HDLc metabolism or maturation.<br /> (© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.)
Details
- Language :
- English
- ISSN :
- 2472-1972
- Volume :
- 6
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of the Endocrine Society
- Publication Type :
- Academic Journal
- Accession number :
- 35382499
- Full Text :
- https://doi.org/10.1210/jendso/bvac034