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Metal-free hydroalkoxylation of ynesulfonamides with alcohols.

Authors :
Wang H
Hu M
Wang XN
Chang J
Source :
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Apr 20; Vol. 20 (16), pp. 3408-3412. Date of Electronic Publication: 2022 Apr 20.
Publication Year :
2022

Abstract

Efforts for developing a convenient and expeditious method for synthesizing alkoxy-substituted enamides via nucleophilic addition of alcohols to ynesulfonamides are described. This sequence is completely regioselective and highly stereoselective, and leads to the hydroalkoxylation products in high yields under mild reaction conditions.

Subjects

Subjects :
Catalysis
Alcohols
Metals

Details

Language :
English
ISSN :
1477-0539
Volume :
20
Issue :
16
Database :
MEDLINE
Journal :
Organic & biomolecular chemistry
Publication Type :
Academic Journal
Accession number :
35380156
Full Text :
https://doi.org/10.1039/d2ob00420h