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Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges.
- Source :
-
Trends in molecular medicine [Trends Mol Med] 2022 May; Vol. 28 (5), pp. 388-404. Date of Electronic Publication: 2022 Apr 01. - Publication Year :
- 2022
-
Abstract
- Stem cell-based therapy for retinal degeneration is transitioning from the research stage to the clinical stage and is being developed as a treatment across the globe. In clinical studies on induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) transplantation, the safety of the technique has started to clarify, and clinical study on further advances such as the long-desired transplantation of iPSC-derived retina to treat retinitis pigmentosa (RP) has begun. Ophthalmologists are now working closely with basic researchers to incorporate new technology areas with a synergy that is anticipated to realize the practical application of stem cell-based therapy for retinal degeneration.<br />Competing Interests: Declaration of interests None are declared.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-499X
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Trends in molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 35370091
- Full Text :
- https://doi.org/10.1016/j.molmed.2022.03.001