Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage.

Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH.
Materials & Methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH.
Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume.
Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH.
Competing Interests: Financial & competing interests disclosure This work was supported by the Departamento de Ciência e Tecnologia (DECIT) do Ministério da Saúde and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq: 402319/2013-3), the Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 88887.136364/2017-00, 88887.199249/2018-00; and PROBITEC: 2262/2012 – 23038.004161/2018-88), and the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ; E-26/010.002487/2016, Edital 19/2016). The authors also thank the Brazilian funding sources (CAPES, CNPq and FAPERJ) for granting scholarships that made this study possible. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
(© 2022 The Authors.)