Back to Search
Start Over
Immunogenetic Determinants of Parkinson's Disease Etiology.
- Source :
-
Journal of Parkinson's disease [J Parkinsons Dis] 2022; Vol. 12 (s1), pp. S13-S27. - Publication Year :
- 2022
-
Abstract
- Parkinson's disease (PD) is increasingly recognised as a systemic disorder in which inflammation might play a causative role rather than being a consequence or an epiphenomenon of the neurodegenerative process. Although growing genetic evidence links the central and peripheral immune system with both monogenic and sporadic PD, our understanding on how the immune system contributes to PD pathogenesis remains a daunting challenge. In this review, we discuss recent literature aimed at exploring the role of known genes and susceptibility loci to PD pathogenesis through immune system related mechanisms. Furthermore, we outline shared genetic etiologies and interrelations between PD and autoimmune diseases and underlining challenges and limitations faced in the translation of relevant allelic and regulatory risk loci to immune-pathological mechanisms. Lastly, with the field of immunogenetics expanding rapidly, we place these insights into a future context highlighting the prospect of immune modulation as a promising disease-modifying strategy.
- Subjects :
- Causality
Humans
Immune System
Immunogenetics
Inflammation
Parkinson Disease genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1877-718X
- Volume :
- 12
- Issue :
- s1
- Database :
- MEDLINE
- Journal :
- Journal of Parkinson's disease
- Publication Type :
- Academic Journal
- Accession number :
- 35367971
- Full Text :
- https://doi.org/10.3233/JPD-223176