Elevated Pre-operative D-Dimer Levels Do Not Impact the Effect of Tranexamic Acid on Revision Total Knee Arthroplasty.

The purpose of this study was to determine if elevated pre-operative D-dimer levels in patients undergoing revision total knee arthroplasty (rTKA) pose an increased risk of: (1) post-operative venous thromboemboli (VTE); (2) intra-operative blood loss; and (3) need for transfusion of blood products. Eighty-nine patients who underwent rTKA by a single surgeon between January 1, 2017, and December 31, 2019, met the inclusion criteria. Elevated pre-operative D-dimer levels did not pose an increased risk of VTE, blood loss, or transfusion of blood products, demonstrating that elevated pre-operative D-dimer is not a contraindication to the use of tranexamic acid for rTKA.
Competing Interests: Disclosure M.A. Mont is a board or committee member for The Knee Society and The Hip Society, receives research support from National Institutes of Health, and is on the editorial board for the Journal of Arthroplasty, Journal of Knee Surgery, Surgical Technology International, and Orthopaedics. He also receives company support from 3M, Centrexion, Ceras Health, Flexion Therapeutics, Johnson & Johnson, Kolon TissueGene, NXSCI, US Medical Innovations, Pacira, Pfizer-Lily, Skye Biologics, SOLVD Health, Smith and Nephew, Stryker, CERAS Health, MirrorAR, Peerwell, US Medical Innovations, Johnson & Johnson, RegenLab, TissueGene, Stryker, MedicusWorks LLC, Up-to Date, Wolters Kluwer Health–Lippincott Williams & Wilkins, Journal of Arthroplasty, Journal of Knee Surgery, Orthopedics, Surgical Techniques International; AAHKS, Knee Society, and Hip Society. Dr Giles R. Scuderi receives royalties and/or is a consultant for Zimmer Biomet, 3M KCI, Elsevier, Springer, Thieme, and World Scientific. He has stock options in Force Therapeutics and ROM Tech. G.R. Scuderi is also on the editorial board for the Journal of Knee Surgery and is a board member for Operation Walk USA. All other authors have no conflicts of interest to disclose.
(Copyright © 2021 Elsevier Inc. All rights reserved.)