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VAMP2 Expression and Genotype Are Possible Discriminators in Different Forms of Dementia.
- Source :
-
Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Mar 14; Vol. 14, pp. 858162. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Vascular alterations often overlap with neurodegeneration, resulting in mixed forms of dementia (MD) that are hard to differentiate from Alzheimer's Disease (AD). The 26 bp intergenic polymorphism of VAMP2 , a key component of SNARE complex, as well as its mRNA and protein levels are associated with neurological diseases. We evaluated ApoE4 and VAMP2 26 bp Ins/Del genotype distribution in 177 AD, 132 MD, 115 Mild Cognitive Impairment (MCI) and 250 individuals without cognitive decline (CT), as well as VAMP2 gene expression in a subset of 73 AD, 122 MD, 103 MCI and 140 CT. Forty-two MCI evolved to AD (22 MCI-AD) or MD (20 MCI-MD) over time. VAMP2 mRNA was higher in MD compared to AD ( p = 0.0013) and CT ( p = 0.0017), and in MCI-MD compared to MCI-AD ( p < 0.001) after correcting for age, gender, MMSE and ApoE4 +/- covariates ( p <subscript> c </subscript> = 0.004). A higher VAMP2 expression was observed in subjects carrying the minor allele Del compared to those carrying the Ins/Ins genotype ( p = 0.012). Finally, Del/Del genotype was more frequently carried by MD/MCI-MD compared to CT ( p <subscript> c </subscript> = 0.036). These results suggest that VAMP2 mRNA expression can discriminate mixed form of dementia from AD, possibly being a biomarker of AD evolution in MCI patients.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Costa, Ferri, Guerini, Rossi, Arosio and Clerici.)
Details
- Language :
- English
- ISSN :
- 1663-4365
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Frontiers in aging neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 35360211
- Full Text :
- https://doi.org/10.3389/fnagi.2022.858162