Focal Epilepsy in Individuals with Laron Syndrome.

Authors :: Goldberg L
Laron Z
Kornreich L
Scheuerman O
Goldberg-Stern H
Kraus D
Source :: Hormone research in paediatrics [Horm Res Paediatr] 2022; Vol. 95 (3), pp. 286-290. Date of Electronic Publication: 2022 Mar 31.
Publication Year :: 2022
Abstract: Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS).<br />Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS.<br />Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications.<br />Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.<br /> (© 2022 The Author(s). Published by S. Karger AG, Basel.)