Metabolism of a New Dipeptide Neuroprotector in Rats.

Authors :: Kolyvanov GB
Bochkov PO
Litvin AA
Shevchenko RV
Podol'ko AL
Kravtsova OY
Kolyasnikova KN
Zherdev VP
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 Mar; Vol. 172 (5), pp. 579-582. Date of Electronic Publication: 2022 Mar 30.
Publication Year :: 2022
Abstract: Metabolism of a new neuroprotector GZK-111 (N-phenylacetylglycyl-L-proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotransformation are hydrolysis of the ester bond by esterases followed by degradation of the resulting metabolite, as well as reactions leading to the formation of phenylacetic acid and cycloprolylglycine that exhibits neuropsychotropic activity.<br /> (© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)