Back to Search
Start Over
Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2022 May 05; Vol. 922, pp. 174917. Date of Electronic Publication: 2022 Mar 25. - Publication Year :
- 2022
-
Abstract
- Cardiac hypertrophy occurs as a result of high levels of thyroid hormone, which may contribute to heart failure and is closely related to oxidative stress. Hydrogen is a good antioxidant. In this study, we found that intragastric levothyroxine administration for two weeks caused obvious cardiac hypertrophy without reduced systolic function. Additionally, hydrogen inhalation ameliorated the levothyroxine-induced metabolic increase and cardiac hypertrophy in rats. Serum brain natriuretic peptide expression was also attenuated by hydrogen treatment. However, hydrogen had no significant effect on levothyroxine -induced serum troponin I and serum thyroid hormone changes. Hydrogen treatment also reduced the levothyroxine-induced increase in cardiac malondialdehyde, 8-hydroxy-2-deoxyguanosine and serum hydrogen peroxide levels and upregulated superoxide dismutase and glutathione peroxidase activity. Additionally, western blotting results showed that hydrogen inhalation inhibited the expression of cardiac nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2), angiotensin II type 1 receptor, sarcoplasmic reticulum Ca <superscript>2+</superscript> -ATPase (SERCA2), phospho-phospholamban and α-myosin heavy chain proteins. In conclusion, the present study revealed a protective effect of hydrogen on levothyroxine -induced cardiac hypertrophy by regulating angiotensin II type 1 receptors and NOX2-mediated oxidative stress in rats.<br /> (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Subjects :
- Angiotensin II pharmacology
Animals
Antioxidants metabolism
Antioxidants pharmacology
Cardiomegaly chemically induced
Cardiomegaly drug therapy
Cardiomegaly metabolism
NADPH Oxidase 2 metabolism
NADPH Oxidases metabolism
Oxidative Stress
Rats
Thyroid Hormones metabolism
Thyroxine pharmacology
Hydrogen pharmacology
Hydrogen therapeutic use
Receptor, Angiotensin, Type 1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 922
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 35341785
- Full Text :
- https://doi.org/10.1016/j.ejphar.2022.174917