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Synergistic effect of compounds directed to triosephosphate isomerase, a combination to develop drug against trichomoniasis.
- Source :
-
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 Jun; Vol. 355 (6), pp. e2200046. Date of Electronic Publication: 2022 Mar 25. - Publication Year :
- 2022
-
Abstract
- The development of new drugs is continuous in the world; currently, saving resources (both economic ones and time) and preventing secondary effects have become a necessity for drug developers. Trichomoniasis is the most common nonviral sexually transmitted infection affecting more than 270 million people around the world. In our research group, we focussed on developing a selective and more effective drug against Trichomonas vaginalis, and we previously reported on a compound, called A4, which had a trichomonacidal effect. Later, we determined another compound, called D4, which also had a trichomonacidal effect together with favorable toxicity results. Both A4 and D4 are directed at the enzyme triosephosphate isomerase. Thus, we made combinations between the two compounds, in which we determined a synergistic effect against T. vaginalis, determining the IC <subscript>50</subscript> and the toxicity of the best relationship to obtain the trichomonacidal effect. With these results, we can propose a combination of compounds that represents a promising alternative for the development of a new therapeutic strategy against trichomoniasis.<br /> (© 2022 Deutsche Pharmazeutische Gesellschaft.)
Details
- Language :
- English
- ISSN :
- 1521-4184
- Volume :
- 355
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archiv der Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 35332589
- Full Text :
- https://doi.org/10.1002/ardp.202200046