Back to Search
Start Over
Clinical Feasibility of Structural and Functional MRI in Free-Breathing Neonates and Infants.
- Source :
-
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2022 Jun; Vol. 55 (6), pp. 1696-1707. Date of Electronic Publication: 2022 Mar 21. - Publication Year :
- 2022
-
Abstract
- Background: Evaluation of structural lung abnormalities with magnetic resonance imaging (MRI) has previously been shown to be predictive of clinical neonatal outcomes in preterm birth. MRI during free-breathing with phase-resolved functional lung (PREFUL) may allow for complimentary functional information without exogenous contrast.<br />Purpose: To investigate the feasibility of structural and functional pulmonary MRI in a cohort of neonates and infants with no cardiorespiratory disease. Macrovascular pulmonary blood flows were also evaluated.<br />Study Type: Prospective.<br />Population: Ten term infants with no clinically defined cardiorespiratory disease were imaged. Infants recruited from the general population and neonatal intensive care unit (NICU) were studied.<br />Field Strength/sequence: T <subscript>1</subscript> -weighted VIBE, T <subscript>2</subscript> -weighted BLADE uncorrected for motion. Ultrashort echo time (UTE) and 3D-flow data were acquired during free-breathing with self-navigation and retrospective reconstruction. Single slice 2D-gradient echo (GRE) images were acquired during free-breathing for PREFUL analysis. Imaging was performed at 3 T.<br />Assessment: T <subscript>1</subscript> , T <subscript>2</subscript> , and UTE images were scored according to the modified Ochiai scheme by three pediatric body radiologists. Ventilation/perfusion-weighted maps were extracted from free-breathing GRE images using PREFUL analysis. Ventilation and perfusion defect percent (VDP, QDP) were calculated from the segmented ventilation and perfusion-weighted maps. Time-averaged cardiac blood velocities from three-dimensional-flow were evaluated in major pulmonary arteries and veins.<br />Statistical Test: Intraclass correlation coefficient (ICC).<br />Results: The ICC of replicate structural scores was 0.81 (95% CI: 0.45-0.95) across three observers. Elevated Ochiai scores, VDP, and QDP were observed in two NICU participants. Excluding these participants, mean ± standard deviation structural scores were 1.2 ± 0.8, while VDP and QDP were 1.0% ± 1.1% and 0.4% ± 0.5%, respectively. Main pulmonary arterial blood flows normalized to body surface area were 3.15 ± 0.78 L/min/m <superscript>2</superscript> .<br />Data Conclusion: Structural and functional pulmonary imaging is feasible using standard clinical MRI hardware (commercial whole-body 3 T scanner, table spine array, and flexible thoracic array) in free-breathing infants.<br />Evidence Level: 2 TECHNICAL EFFICACY: Stage 1.<br /> (© 2022 International Society for Magnetic Resonance in Medicine.)
Details
- Language :
- English
- ISSN :
- 1522-2586
- Volume :
- 55
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Publication Type :
- Academic Journal
- Accession number :
- 35312203
- Full Text :
- https://doi.org/10.1002/jmri.28165