Leptin Alleviates Inflammatory Response in Myocardial Ischemia Reperfusion Injury.

Objective: To investigate the role of leptin in regulating cell inflammation and protecting myocardium after myocardial ischemia-reperfusion injury in rats through signaling pathway at tissue and molecular protein levels.
Methods: Healthy female SD rats were randomly divided into 4 groups, which were sham, I/R group, leptin low-dose intervention group, and high-dose intervention group (40  μ g/kg and 80  μ g/kg, respectively). Cardiac hemodynamics, myocardial enzymology, inflammatory indices, and pathological changes were observed. Western blot was used to observe the expression of PI3K, AKT, and NF κ B protein by leptin.
Results: Leptin can improve the hemodynamics of cardiac ischemia-reperfusion rats, improve the expression of myocardial enzymology, reduce the release of cardiac and serum inflammatory factors, increased PI3k, AKT, and NF κ B expression, and reduce the occurrence of inflammation from the perspective of gross pathology, thus protecting the body.
Conclusion: Leptin pretreatment can reduce MIRI injury, and the protective mechanism may be that leptin upregulates PI3K-AKT-NF κ B expression in myocardial tissue to reduce inflammation and promote repair of I/R injury.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Shu Xu and Dengshun Tao.)