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The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive Rats.
- Source :
-
Planta medica [Planta Med] 2022 Oct; Vol. 88 (13), pp. 1152-1162. Date of Electronic Publication: 2022 Mar 17. - Publication Year :
- 2022
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Abstract
- Blutaparon portulacoides is a Brazilian plant species that is widely used in folk medicine. The present study investigated the role of an aqueous extract of B. portulacoides against hypertension in spontaneously hypertensive rats. The aqueous extract of B. portulacoides was obtained from the whole plant. Its chemical profile was analyzed by ultraperformance liquid chromatography-tandem mass spectrometry. The acute toxicity of the aqueous extract of B. portulacoides was evaluated in female Wistar rats. Male 6-month-old spontaneously hypertensive rats then received the aqueous extract of B. portulacoides (30, 100, and 300 mg/kg), hydrochlorothiazide (25 mg/kg), or vehicle once daily for 28 days. On days 1, 14, and 28, the diuretic effects of the aqueous extract of B. portulacoides were evaluated. The role of prostaglandins and the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway in the diuretic activity of the aqueous extract of B. portulacoides was also investigated. At the end of the treatment, hepatic and renal biochemical markers, serum nitrotyrosine, malondialdehyde, nitrite, and aldosterone levels, and angiotensin-converting enzyme activity were measured. The electrocardiographic profile, blood pressure, and renal vascular reactivity were also assessed. The heart, kidneys, and liver were collected to determine relative organ weight, histopathology, and cardiac morphometry. Caffeic acid, ferulic acid, and several flavonoids were identified in the aqueous extract of B. portulacoides . No signs of toxicity were observed. Prolonged treatment with the aqueous extract of B. portulacoides (300 mg/kg) induced significant diuretic activity by activating the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway. These effects reduced blood pressure and oxidative stress and prevented renal vascular dysfunction and left ventricular hypertrophy that was induced by hypertension. Overall, the present data suggest that the aqueous extract of B. portulacoides has important diuretic and cardioprotective effects by activation of the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Thieme. All rights reserved.)
- Subjects :
- Rats
Animals
Diuretics pharmacology
Rats, Inbred SHR
Nitric Oxide metabolism
Nitrites metabolism
Nitrites pharmacology
Aldosterone pharmacology
Guanosine Monophosphate pharmacology
Rats, Wistar
Plant Extracts pharmacology
Blood Pressure
Cyclic GMP metabolism
Hydrochlorothiazide pharmacology
Prostaglandins pharmacology
Potassium Channels
Biomarkers
Flavonoids pharmacology
Malondialdehyde
Angiotensins metabolism
Angiotensins pharmacology
Antihypertensive Agents pharmacology
Hypertension drug therapy
Amaranthaceae
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 88
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 35299274
- Full Text :
- https://doi.org/10.1055/a-1690-3566