Back to Search
Start Over
Mechanistic analysis by NMR spectroscopy: A users guide.
- Source :
-
Progress in nuclear magnetic resonance spectroscopy [Prog Nucl Magn Reson Spectrosc] 2022 Apr; Vol. 129, pp. 28-106. Date of Electronic Publication: 2022 Jan 19. - Publication Year :
- 2022
-
Abstract
- A 'principles and practice' tutorial-style review of the application of solution-phase NMR in the analysis of the mechanisms of homogeneous organic and organometallic reactions and processes. This review of 345 references summarises why solution-phase NMR spectroscopy is uniquely effective in such studies, allowing non-destructive, quantitative analysis of a wide range of nuclei common to organic and organometallic reactions, providing exquisite structural detail, and using instrumentation that is routinely available in most chemistry research facilities. The review is in two parts. The first comprises an introduction to general techniques and equipment, and guidelines for their selection and application. Topics include practical aspects of the reaction itself, reaction monitoring techniques, NMR data acquisition and processing, analysis of temporal concentration data, NMR titrations, DOSY, and the use of isotopes. The second part comprises a series of 15 Case Studies, each selected to illustrate specific techniques and approaches discussed in the first part, including in situ NMR ( <superscript>1/2</superscript> H, <superscript>10/11</superscript> B, <superscript>13</superscript> C, <superscript>15</superscript> N, <superscript>19</superscript> F, <superscript>29</superscript> Si, <superscript>31</superscript> P), kinetic and equilibrium isotope effects, isotope entrainment, isotope shifts, isotopes at natural abundance, scalar coupling, kinetic analysis (VTNA, RPKA, simulation, steady-state), stopped-flow NMR, flow NMR, rapid injection NMR, pure shift NMR, dynamic nuclear polarisation, <superscript>1</superscript> H/ <superscript>19</superscript> F DOSY NMR, and in situ illumination NMR.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Subjects :
- Kinetics
Magnetic Resonance Spectroscopy methods
Isotopes
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3301
- Volume :
- 129
- Database :
- MEDLINE
- Journal :
- Progress in nuclear magnetic resonance spectroscopy
- Publication Type :
- Academic Journal
- Accession number :
- 35292133
- Full Text :
- https://doi.org/10.1016/j.pnmrs.2022.01.001