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The evaluation of vancomycin-resistant enterococci and carbapenamase producing Klebsiella colonization among ICU-Hospitalized Patients.
- Source :
-
African health sciences [Afr Health Sci] 2021 Dec; Vol. 21 (4), pp. 1662-1668. - Publication Year :
- 2021
-
Abstract
- Background: Multi-drug resistant organisms, especially Vancomycin-Resistant Enterococcus (VRE) and Carbapenam Resistant Klebsiella pneumoniae (KPC), are serious health threat. Early detection of resistant bacteria colonization among patients in intensive care units (ICUs) not only enables effective treatment but more importantly prevents disease and limits transmission. Therefore, we aimed to to assess the frequency of VRE and KPC colonization via rectal swab sampling.<br />Methods: The study was carried out in ICUs of a tertiary hospital. Two rectal swab samples were collected within the first 24 hours of admission and another one was taken every subsequent 15 days to test for for VRE and KPC carriage.<br />Results: A total 316 rectal swab samples taken from 230 patients. Forty-seven patients were screened at least 2 times. 183 patients were not further screened due to discharge, exitus or transfer to other wards. Thirty-six patients (16%) were determined to be VRE (+). The most frequently isolated strain was E. faecium (80.5%) and its most common genotype was VanA (87.5%). Seven patients (3%) were identified as KPC (+). OXA-48 type crbapenamase was confirmed in all KPC isolates.<br />Conclusion: This study shows that VRE and KPC colonization continues to be a serious threat in ICUs.<br /> (© 2021 Karaşin G et al.)
- Subjects :
- Carbapenems metabolism
Carbapenems pharmacology
Carbapenems therapeutic use
Carrier State diagnosis
Carrier State microbiology
Hospitalization
Humans
Intensive Care Units
Klebsiella genetics
Klebsiella isolation & purification
Klebsiella metabolism
Klebsiella pneumoniae genetics
Klebsiella pneumoniae metabolism
Rectum microbiology
beta-Lactam Resistance genetics
Carbapenem-Resistant Enterobacteriaceae genetics
Carbapenem-Resistant Enterobacteriaceae isolation & purification
Carbapenem-Resistant Enterobacteriaceae metabolism
Klebsiella Infections diagnosis
Klebsiella Infections metabolism
Klebsiella Infections microbiology
Vancomycin Resistance genetics
Vancomycin-Resistant Enterococci genetics
Vancomycin-Resistant Enterococci isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1729-0503
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- African health sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35283955
- Full Text :
- https://doi.org/10.4314/ahs.v21i4.20