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True hyponatremia in the setting of pegasparagase-induced hypertriglyceridemia: A case report.
- Source :
-
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2022 Jun 01; Vol. 531, pp. 68-70. Date of Electronic Publication: 2022 Mar 10. - Publication Year :
- 2022
-
Abstract
- Pegasparagase (PEG-Asparaginase) induced hypertriglyceridemia is rare in the treatment of lymphoblastic lymphoma in children. We present a case of PEG-asparaginase induced hypertriglyceridemia that was incidentally identified and suspicion of its interference with sodium measurement in the clinical laboratory. The use of a direct ion selective method clarified the presence of true hyponatremia. The patient was treated with an oral Fenofibrate therapy which resolved the hypertriglyceridemia. This case highlights that PEG-asparaginanse and Olazanpine can induce hypertriglyceridemia in acute lymphoblastic leukemia and it may be useful to obtain baseline triglyceride measurements for these patients.<br /> (Copyright © 2022. Published by Elsevier B.V.)
- Subjects :
- Asparaginase adverse effects
Child
Humans
Polyethylene Glycols adverse effects
Antineoplastic Agents therapeutic use
Hypertriglyceridemia chemically induced
Hypertriglyceridemia complications
Hypertriglyceridemia drug therapy
Hyponatremia chemically induced
Hyponatremia drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3492
- Volume :
- 531
- Database :
- MEDLINE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35283095
- Full Text :
- https://doi.org/10.1016/j.cca.2022.02.017