Self-organization and surface properties of hBest1 in models of biological membranes.

Authors :: Doumanov JA
Mladenova K
Moskova-Doumanova V
Andreeva TD
Petrova SD
Source :: Advances in colloid and interface science [Adv Colloid Interface Sci] 2022 Apr; Vol. 302, pp. 102619. Date of Electronic Publication: 2022 Feb 22.
Publication Year :: 2022
Abstract: The transmembrane Ca <superscript>2+</superscript>  - activated Cl <superscript>-</superscript> channel - human bestrophin-1 (hBest1) is expressed in retinal pigment epithelium and mutations of BEST1 gene cause ocular degenerative diseases colectivelly referred to as "bestrophinopathies". A large number of genetical, biochemical, biophysical and molecular biological studies have been performed to understand the relationship between structure and function of the hBest1 protein and its pathophysiological significance. Here, we review the current understanding of hBest1 surface organization, interactions with membrane lipids in model membranes, and its association with microdomains of cellular membranes. These highlights are significant for modulation of channel activity in cells.<br /> (Copyright © 2022 Elsevier B.V. All rights reserved.)

Subjects :: Bestrophins chemistry
Bestrophins metabolism
Cell Membrane chemistry
Humans
Surface Properties
Chloride Channels genetics
Chloride Channels metabolism
Eye Proteins genetics
Eye Proteins metabolism

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