Debugging the gut-brain axis in depression.

In this issue of Cell Host & Microbe, Li et al. take a step toward a better understanding of the microbiome-gut-brain axis in mental health. They report gastrointestinal testosterone degradation by a specific bacterial strain as a potential mechanism impacting symptom expression in males with depression.
Competing Interests: Declaration of interests G.C. has received honoraria from Janssen, Probi, and Apsen as an invited speaker; is in receipt of research funding from Pharmavite, Fonterra, Nestle, and Reckitt; and is a paid consultant for Yakult, Zentiva, and Heel Pharmaceuticals. J.F.C. has been an invited speaker at conferences organized by Mead Johnson, Alkermes, Janssen, Ordesa, and Yakult and has received research funding from Mead Johnson, Cremo, Nutricia, Pharmavite, Dupont, and 4D Pharma. The content of this preview was neither influenced nor constrained by this support.
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