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Sex differences in clinical outcomes for obstructive hypertrophic cardiomyopathy in the USA: a retrospective observational study of administrative claims data.
- Source :
-
BMJ open [BMJ Open] 2022 Mar 09; Vol. 12 (3), pp. e058151. Date of Electronic Publication: 2022 Mar 09. - Publication Year :
- 2022
-
Abstract
- Objectives: To evaluate sex differences in demographic and clinical characteristics, treatments and outcomes for patients with diagnosed obstructive hypertrophic cardiomyopathy (oHCM) in the USA.<br />Setting: Retrospective observational study of administrative claims data from MarketScan Commercial Claims and Encounters Database from IBM Watson Health.<br />Participants: Of the 28 million covered employees and family members in MarketScan, 9306 patients with oHCM were included in this analysis.<br />Main Outcome Measures: oHCM-related outcomes included heart failure, atrial fibrillation, ventricular tachycardia/ fibrillation, sudden cardiac death, septal myectomy, alcohol septal ablation (ASA) and heart transplant.<br />Results: Among 9306 patients with oHCM, the majority were male (60.5%, p<0.001) and women were of comparable age to men (50±15 vs 49±15 years, p<0.001). Women were less likely to be prescribed beta blockers (42.7% vs 45.2%, p=0.017) and undergo an implantable cardioverter-defibrillator (1.7% vs 2.6%, p=0.005). Septal reduction therapy was performed slightly more frequently in women (ASA: 0.08% vs 0.05%, p=0.600; SM: 0.35% vs 0.18%, p=0.096), although not statistically significant. Women were less likely to have atrial fibrillation (6.7% vs 9.9%, p<0.001).<br />Conclusion: Women were less likely to be prescribed beta blockers, ACE inhibitors, anticoagulants, undergo implantable cardioverter-defibrillator and have ventricular tachycardia/fibrillation. Men were more likely to have atrial fibrillation. Future research using large, clinical real-world data are warranted to understand the root cause of these potential treatment disparities in women with oHCM.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Death, Sudden, Cardiac
Female
Humans
Male
Retrospective Studies
Sex Characteristics
Treatment Outcome
Ventricular Fibrillation
Atrial Fibrillation epidemiology
Atrial Fibrillation etiology
Atrial Fibrillation therapy
Cardiomyopathy, Hypertrophic epidemiology
Cardiomyopathy, Hypertrophic therapy
Defibrillators, Implantable adverse effects
Tachycardia, Ventricular epidemiology
Tachycardia, Ventricular therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2044-6055
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- BMJ open
- Publication Type :
- Academic Journal
- Accession number :
- 35264369
- Full Text :
- https://doi.org/10.1136/bmjopen-2021-058151