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Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 15; Vol. 119 (11), pp. e2119415119. Date of Electronic Publication: 2022 Mar 08. - Publication Year :
- 2022
-
Abstract
- SignificanceHosts often target the relatively conserved regions in rapidly mutating retroviruses to inhibit their replication. One of these regions is called a primer binding site (PBS), which has to be complementary to the host tRNA to initiate reverse transcription. By analyzing endogenous retroviral elements, we found that host cells use this sequence as a target in efforts to block the expression of viral elements. A specific type of zinc finger protein targets the PBS in a host genome, which not only inhibits the transcription of endogenous viruses but also inhibits the replication of exogenous retroviruses with the same PBS. Thus, our study sheds light on a strategy for searching for host restriction factors targeting retroviruses.
- Subjects :
- Base Sequence
Binding Sites
Chromosome Mapping
Endogenous Retroviruses
Genome-Wide Association Study
Humans
Nucleotide Motifs
Retroviridae classification
Transcription, Genetic
Virus Replication
Gene Expression Regulation, Viral
Host-Pathogen Interactions
RNA, Viral genetics
RNA, Viral metabolism
Repressor Proteins metabolism
Retroviridae physiology
Zinc Fingers
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 119
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 35259018
- Full Text :
- https://doi.org/10.1073/pnas.2119415119