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Predictors of type-2 diabetes remission following bariatric surgery after a two-year follow-up.
- Source :
-
Asian journal of surgery [Asian J Surg] 2022 Dec; Vol. 45 (12), pp. 2645-2650. Date of Electronic Publication: 2022 Mar 04. - Publication Year :
- 2022
-
Abstract
- Purpose: Bariatric surgery is evolving as a successful tool for managing morbid obesity and T2DM. This study aimed to identify predictors of diabetes remission after two types of bariatric procedures.<br />Methods: This prospective study enrolled 172 patients with morbid obesity associated with T2DM scheduled for bariatric surgery. Two laparoscopic bariatric procedures were done; single anastomosis gastric bypass (SAGB, n = 83) and sleeve gastrectomy (LSG, n = 68). Lipid accumulation product index (LAP) and quantitative insulin sensitivity check index (QUICKI) were used to evaluate lipid profile and insulin sensitivity. Two years after surgery condition of DM was evaluated as complete remission (CR), partial remission (PR), or improvement. The primary outcome measure was predictors of diabetes remission.<br />Results: Two years after surgery, 151 patients were available for evaluation, where 75 patients (49.7%) achieved CR, while PR was found in 36 (23.8%). CR was significantly associated with younger age, shorter duration of DM (p < 0.001, for both), higher C-peptide and GLP-1 levels (p < 0.001 and p = 0.002, respectively), and bypass surgery (p = 0.027). On multivariate analysis, shorter duration of DM, lower BMI, and higher C-peptide levels were the independent factors predicting CR.<br />Conclusion: Complete remission of T2DM can be achieved in nearly half of the patients two years after SG or SAGB. The duration of diabetes and preoperative BMI and C-peptide levels are the independent factors predicting complete remissions.<br />Competing Interests: Declaration of competing interest None to declare.<br /> (Copyright © 2022 Asian Surgical Association and Taiwan Robotic Surgery Association. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
C-Peptide
Follow-Up Studies
Prospective Studies
Blood Glucose
Treatment Outcome
Gastrectomy methods
Retrospective Studies
Obesity, Morbid complications
Obesity, Morbid surgery
Insulin Resistance
Bariatric Surgery methods
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 surgery
Gastric Bypass methods
Laparoscopy methods
Subjects
Details
- Language :
- English
- ISSN :
- 0219-3108
- Volume :
- 45
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Asian journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 35256262
- Full Text :
- https://doi.org/10.1016/j.asjsur.2021.12.070