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Antigen-specific B cell tumors of mice.
- Source :
-
Critical reviews in immunology [Crit Rev Immunol] 1986; Vol. 6 (2), pp. 105-21. - Publication Year :
- 1986
-
Abstract
- The topics covered in this review include: the origin and availability of murine B cell lymphomas bearing immunoglobulins of known antigen reactivity; their etiology and the role of antigen in lymphomagenesis; the extent to which such tumors are true analogs of normal B cells; and the knowledge of B cell differentiation which has been derived from the study of these cells. There is little or no evidence that B lymphomas with preselected antigen specificity can be induced at will. However, there is evidence that genetic factors influencing idiotype specific regulation can predispose particular subsets of B cells to neoplastic transformation, and thereby indirectly influence the antigen specificity of the resultant lymphomas. The bulk of evidence suggests that, except for growth control characteristics, recently derived B cell lymphomas retain many of the features of normal lymphocytes. Thus, mechanisms elucidated by study of lymphomas are probably reflective of normal B cell biology.
- Subjects :
- Animals
B-Lymphocytes cytology
Cell Division
Cell Line
H-2 Antigens genetics
Hybridomas immunology
Immunity
Immunoglobulin Idiotypes genetics
Immunoglobulins analysis
Mice
Plasmacytoma immunology
T-Lymphocytes immunology
Antigens, Neoplasm immunology
B-Lymphocytes immunology
Lymphoma immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1040-8401
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Critical reviews in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 3524998