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Tubular basement membrane deposits in human renal allografts.
- Source :
-
Biomedicine / [publiee pour l'A.A.I.C.I.G.] [Biomedicine] 1978 Feb; Vol. 29 (1), pp. 18-21. - Publication Year :
- 1978
-
Abstract
- In 18 patients who received renal allografts, tubulo-interstitial lesions were studied, according to the types of rejection or the possible recurrence of primary disease. Immunofluorescent (IF) investigation revealed tubular basement membrane (TBM) deposits of IgG and/or C3 and sometimes other components of Complement. The pattern of these deposits was: "linear" in 3 cases, "granular" in 9 cases and "atypical" with linear and granular segments in 6 cases. The IF study of own kidneys of 3 patients, before the transplantation, revealed no TBM deposits. TBM deposits were accompanied by arterial wall deposits of IgM and/or C3 and sometimes C5 in 17 cases. Electron-microscopy study of renal tubules showed thickening, lamellation and/or deposits along the tubular basement membrane. The immunopathogenesis of these deposits was discussed.
- Subjects :
- Antibodies, Anti-Idiotypic analysis
Arteries immunology
Complement C3 analysis
Graft Rejection
Humans
Immunoglobulin M analysis
Kidney Tubules immunology
Recurrence
Transplantation, Homologous
Basement Membrane immunology
Kidney Transplantation
Kidney Tubules ultrastructure
Transplantation Immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0893
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomedicine / [publiee pour l'A.A.I.C.I.G.]
- Publication Type :
- Academic Journal
- Accession number :
- 352420