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In vivo mutagenic effects and oxidative stress parameters evaluation of cypermethrin and benzoate of emamectin and their mixtures in female mice.
- Source :
-
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes [J Environ Sci Health B] 2022; Vol. 57 (3), pp. 211-219. Date of Electronic Publication: 2022 Mar 03. - Publication Year :
- 2022
-
Abstract
- We evaluated the biological effects of ingestion by gavage, for 28 days, of the pesticides cypermethrin (CP) and emamectin benzoate (EB) and their mixtures in female Swiss mice. The groups were Control (water); CP; EB and three distinct concentrations of CP and EB mixture expressed in mg/kg/day. The biological effects were analyzed in the complete blood count and plasma (alkaline phosphatase (ALP), alanine aminotransferase (ALT) and creatinine); the biochemical parameters of oxidative stress (substances reactive to thiobarbituric acid (TBARS); reduced glutathione (GSH); catalase (CAT), superoxide dismutase (SOD) and glutathione- S -transferase (GST)), and bone marrow cells obtained from the femur for the micronucleus (MN) test. In the heart, there was a reduction in GSH in the groups (0.5 + 0.67 and 2.5 + 3.37), although in the brain this effect appeared for the other groups, except EB. Brain TBARS increased in CP and in the group (2.5 + 3.37) and platelets increased in the group (12.5 + 16.87). Genotoxic/mutagenic effects, showing a consistent increase dose-dependent effect on micronucleus counting for in the female mice. After 28 days of treatment, we can observe that the pesticide mixtures promoted genotoxic damage and oxidative brain damage in female mice, which can damage the health of these animals and possibly their future offspring.
- Subjects :
- Animals
Antioxidants metabolism
Benzoates pharmacology
Catalase metabolism
Disaccharides
Female
Glutathione metabolism
Glutathione Transferase genetics
Glutathione Transferase metabolism
Ivermectin analogs & derivatives
Liver
Mice
Oxidative Stress
Pyrethrins
Superoxide Dismutase metabolism
Thiobarbituric Acid Reactive Substances
Mutagens
Pesticides toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4109
- Volume :
- 57
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
- Publication Type :
- Academic Journal
- Accession number :
- 35240941
- Full Text :
- https://doi.org/10.1080/03601234.2022.2045841