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The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis.
- Source :
-
Food & function [Food Funct] 2022 Mar 21; Vol. 13 (6), pp. 3185-3197. Date of Electronic Publication: 2022 Mar 21. - Publication Year :
- 2022
-
Abstract
- An N -glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris . Of importance, CMPS-80 significantly ameliorated formation of atherosclerotic lesions and plasma lipid profiles in apolipoprotein E-deficient mice. Integrated informatics analysis suggested that CMPS-80 can modulate multiple lncRNA-microRNA-mRNA axes. CMPS-80 has a potential application for prevention of hyperlipidemia and atherosclerosis.
- Subjects :
- Animals
Atherosclerosis genetics
Atherosclerosis metabolism
Cholesterol blood
Coronary Artery Disease metabolism
Coronary Artery Disease prevention & control
Fungal Proteins chemistry
Gene Expression
Liver metabolism
Mice
Oligonucleotide Array Sequence Analysis
Peptides chemistry
Peptides pharmacology
Polysaccharides chemistry
Proteoglycans
RNA, Long Noncoding metabolism
RNA, Messenger metabolism
Triglycerides blood
Atherosclerosis prevention & control
Cordyceps chemistry
Fungal Proteins pharmacology
MicroRNAs genetics
Polysaccharides pharmacology
RNA, Long Noncoding genetics
RNA, Messenger genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 35225320
- Full Text :
- https://doi.org/10.1039/d1fo03285b