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Pro-resolving therapies as potential adjunct treatment for infectious diseases: Evidence from studies with annexin A1 and angiotensin-(1-7).
- Source :
-
Seminars in immunology [Semin Immunol] 2022 Jan; Vol. 59, pp. 101601. Date of Electronic Publication: 2022 Feb 23. - Publication Year :
- 2022
-
Abstract
- Infectious diseases, once believed to be an eradicable public health threat, still represent a leading cause of death worldwide. Environmental and social changes continuously favor the emergence of new pathogens and rapid dissemination around the world. The limited availability of anti-viral therapies and increased antibiotic resistance has made the therapeutic management of infectious disease a major challenge. Inflammation is a primordial defense to protect the host against invading microorganisms. However, dysfunctional inflammatory responses contribute to disease severity and mortality during infections. In recent years, a few studies have examined the relevance of resolution of inflammation in the context of infections. Inflammation resolution is an active integrated process transduced by several pro-resolving mediators, including Annexin A1 and Angiotensin-(1-7). Here, we examine some of the cellular and molecular circuits triggered by pro-resolving molecules and that may be beneficial in the context of infectious diseases.<br />Competing Interests: Declaration of Competing Interest The authors report no declarations of interest.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1096-3618
- Volume :
- 59
- Database :
- MEDLINE
- Journal :
- Seminars in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 35219595
- Full Text :
- https://doi.org/10.1016/j.smim.2022.101601