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TP53 mutations in head and neck cancer.
- Source :
-
Molecular carcinogenesis [Mol Carcinog] 2022 Apr; Vol. 61 (4), pp. 385-391. Date of Electronic Publication: 2022 Feb 23. - Publication Year :
- 2022
-
Abstract
- Head and neck squamous cell carcinomas (HNSCCs) arising in the mucosal linings of the upper aerodigestive tract are highly heterogeneous, aggressive, and multifactorial tumors affecting more than half a million patients worldwide each year. Classical etiological factors for HNSCC include alcohol, tobacco, and human papillomavirus (HPV) infection. Current treatment options for HNSCCs encompass surgery, radiotherapy, chemotherapy, or combinatorial remedies. Comprehensive integrative genomic analysis of HNSCC has identified mutations in TP53 gene as the most frequent of all somatic genomic alterations. TP53 mutations are associated with either loss of wild-type p53 function or gain of functions that promote invasion, metastasis, genomic instability, and cancer cell proliferation. Interestingly, disruptive TP53 mutations in tumor DNA are associated with aggressiveness and reduced survival after surgical treatment of HNSCC. This review summarizes the current evidence and impact of TP53 mutations in HNSCC.<br /> (© 2022 Wiley Periodicals LLC.)
- Subjects :
- Animals
Humans
Mutation
Papillomaviridae genetics
Squamous Cell Carcinoma of Head and Neck genetics
Tumor Suppressor Protein p53 genetics
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell pathology
Head and Neck Neoplasms genetics
Papillomavirus Infections complications
Papillomavirus Infections genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-2744
- Volume :
- 61
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 35218075
- Full Text :
- https://doi.org/10.1002/mc.23385