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Different but Not Unique: Deciphering the Immunity of the Jamaican Fruit Bat by Studying Its Viriome.
- Source :
-
Viruses [Viruses] 2022 Jan 25; Vol. 14 (2). Date of Electronic Publication: 2022 Jan 25. - Publication Year :
- 2022
-
Abstract
- A specialized and fine-tuned immune response of bats upon infection with viruses is believed to provide the basis for a "friendly" coexistence with these pathogens, which are often lethal for humans and other mammals. First insights into the immunity of bats suggest that bats have evolved to possess their own strategies to cope with viral infections. Yet, the molecular details for this innocuous coexistence remain poorly described and bat infection models are the key to unveiling these secrets. In Jamaican fruit bats (Artibeus jamaicensis) , a New World bat species, infection experiments with its (putative) natural viral pathogens Tacaribe virus (TCRV), rabies virus (RABV), and the bat influenza A virus (IAV) H18N11, have contributed to an accurate, though still incomplete, representation of the bat-imposed immunity. Surprisingly, though many aspects of their innate and adaptive immune responses differ from that of the human immune response, such as a contraction of the IFN locus and reduction in the number of immunoglobulin subclasses, variations could also be observed between Jamaican fruit bats and other bat species.
- Subjects :
- Adaptive Immunity
Animals
Arenaviridae Infections immunology
Arenaviridae Infections veterinary
Arenaviridae Infections virology
Arenaviruses, New World isolation & purification
Immunity, Innate
Influenza A virus isolation & purification
Orthomyxoviridae Infections immunology
Orthomyxoviridae Infections veterinary
Rabies immunology
Rabies veterinary
Rabies virology
Rabies virus isolation & purification
Virus Diseases immunology
Chiroptera immunology
Chiroptera virology
Virome
Virus Diseases veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 35215832
- Full Text :
- https://doi.org/10.3390/v14020238