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β-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection.
- Source :
-
Viruses [Viruses] 2022 Jan 25; Vol. 14 (2). Date of Electronic Publication: 2022 Jan 25. - Publication Year :
- 2022
-
Abstract
- Coriolus versicolor ( C. versicolor ) is a higher fungi or mushroom which is now known by its accepted scientific names as Trametes versicolor (L.) Lloyd. Many studies have shown that β-glucans from C. versicolor have various physiological activities, including activating macrophages to protect against Salmonella infection. However, whether β-glucans have antiviral effects has not been reported. Hence, the objective of this study was to confirm whether β-glucans could boost the immune response to combat influenza virus in mouse and chick models. The results show that β-glucans induced the expression of Dectin-1 , costimulatory molecules ( CD80 / 86 ) and cytokines IL-6 , IL-1β , IFN-β and IL-10 in murine bone marrow dendritic cells (BMDCs). In addition, orally administered β-glucans reduced weight loss, mortality and viral titers in the lungs of mice infected with influenza virus and attenuated pathological lung damage caused by the virus in the mice. Orally administered β-glucans improved survival and reduced lung viral titers in chickens infected with H9N2 avian influenza virus. These results suggest that β-glucans have a significant antiviral effect. Therefore, β-glucans could become a potential immunomodulator against influenza virus.
- Subjects :
- Animals
Antiviral Agents pharmacology
Antiviral Agents therapeutic use
B7-1 Antigen genetics
B7-1 Antigen metabolism
B7-2 Antigen genetics
B7-2 Antigen metabolism
Chickens
Cytokines genetics
Cytokines metabolism
Dendritic Cells metabolism
Female
Gene Expression
Immunologic Factors
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H9N2 Subtype
Influenza in Birds drug therapy
Lectins, C-Type genetics
Lectins, C-Type metabolism
Lung pathology
Lung virology
Male
Mice
Mice, Inbred C57BL
Orthomyxoviridae Infections drug therapy
Orthomyxoviridae Infections pathology
beta-Glucans immunology
beta-Glucans therapeutic use
Dendritic Cells immunology
Influenza in Birds prevention & control
Orthomyxoviridae Infections prevention & control
Polyporaceae chemistry
beta-Glucans pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 35215831
- Full Text :
- https://doi.org/10.3390/v14020237