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Biocompatible Core-Shell-Structured Si-Based NiO Nanoflowers and Their Anticancer Activity.
- Source :
-
Pharmaceutics [Pharmaceutics] 2022 Jan 23; Vol. 14 (2). Date of Electronic Publication: 2022 Jan 23. - Publication Year :
- 2022
-
Abstract
- Compared to most of nano-sized particles, core-shell-structured nanoflowers have received great attention as bioactive materials because of their high surface area with the flower-like structures. In this study, core-shell-structured Si-based NiO nanoflowers, Si@NiO, were prepared by a modified chemical bath deposition method followed by thermal reduction. The crystal morphology and basic structure of the composites were characterized by powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), specific surface area (BET) and porosity analysis (BJT), and inductively coupled plasma optical emission spectrometry (ICP-OES). The electrochemical properties of the Si@NiO nanoflowers were examined through the redox reaction of ascorbic acid with the metal ions present on the surface of the core-shell nanoflowers. This reaction favored the formation of reactive oxygen species. The Si@NiO nanoflowers showed excellent anticancer activity and low cytotoxicity toward the human breast cancer cell line (MCF-7) and mouse embryonic fibroblasts (MEFs), respectively, demonstrating that the anticancer activities of the Si@NiO nanoflowers were primarily derived from the oxidative capacity of the metal ions on the surface, rather than from the released metal ions. Thus, this proves that Si-based NiO nanoflowers can act as a promising candidate for therapeutic applications.
Details
- Language :
- English
- ISSN :
- 1999-4923
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 35214001
- Full Text :
- https://doi.org/10.3390/pharmaceutics14020268