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Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function.

Authors :
Kundu P
Zimmerman B
Quinn JF
Kaye J
Mattek N
Westaway SK
Raber J
Source :
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 86 (3), pp. 1471-1481.
Publication Year :
2022

Abstract

Background: α-klotho might play a role in neurodegenerative diseases.<br />Objective: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR).<br />Methods: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture.<br />Results: Serum and CSF levels of α-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status.<br />Conclusion: Our results demonstrate that α-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of α-klotho from serum is likely highly reflective of CSF levels.

Details

Language :
English
ISSN :
1875-8908
Volume :
86
Issue :
3
Database :
MEDLINE
Journal :
Journal of Alzheimer's disease : JAD
Publication Type :
Academic Journal
Accession number :
35213382
Full Text :
https://doi.org/10.3233/JAD-215719