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Biotechnological production of chiral acetoin.

Biotechnological production of chiral acetoin.

Authors :
Meng W
Ma C
Xu P
Gao C
Source :
Trends in biotechnology [Trends Biotechnol] 2022 Aug; Vol. 40 (8), pp. 958-973. Date of Electronic Publication: 2022 Feb 21.
Publication Year :
2022

Abstract

Acetoin (AC) is an important platform bulk chemical with versatile applications. It exists in two stereoisomeric forms: (3R)-AC and (3S)-AC. Both stereoisomers could be potentially applied in the pharmaceutical industry, agriculture, and in optically active α-hydroxyketone derivative synthesis. Chiral AC production has recently become a new research focus in biotechnology. Fermentative and biocatalytic routes that can produce (3R)-AC or (3S)-AC with high optical purity have been developed over the past several years. In this review we summarize recent advances in strain screening, metabolic engineering, and biocatalytic system construction aimed at improving the production of chiral AC. Limiting factors and possible solutions for chiral AC production are discussed.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-3096
Volume :
40
Issue :
8
Database :
MEDLINE
Journal :
Trends in biotechnology
Publication Type :
Academic Journal
Accession number :
35210122
Full Text :
https://doi.org/10.1016/j.tibtech.2022.01.008