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Heterotrimetallic Double Cavity Cages: Syntheses and Selective Guest Binding.

Authors :: Lisboa LS
Preston D
McAdam CJ
Wright LJ
Hartinger CG
Crowley JD
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Apr 25; Vol. 61 (18), pp. e202201700. Date of Electronic Publication: 2022 Mar 04.
Publication Year :: 2022
Abstract: A strategy for the generation of heterotrimetallic double cavity (DC) cages [Pd <subscript>n</subscript> Pt <subscript>m</subscript> L <subscript>4</subscript> ] <superscript>6+</superscript> (DC1: n=1, m=2; and DC2: n=2, m=1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and Pd <superscript>II</superscript> ions. <superscript>1</superscript> H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2 were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single-crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities, was found to interact with two different guests, 5-FU and cisplatin, selectively.<br /> (© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)