The distribution and structural fingerprints of metals from particulate matters (PM) deposited in human lungs.

This work investigated the distribution and chemical fingerprints of 24 metals in particulate matter (PM) deposited in nonoccupational human lungs. Metals in the pulmonary PM can be grouped by the mean concentration as > 5 × 10 ³ μg/g (Al/Fe/Ca/Mg/Zn), 1-5 × 10 ³ μg/g (Ti/Ba/Pb/Mn), 0.2-1 × 10 ³ μg/g (Cu/Cr/As/V) and < 100 μg/g (Ni/Sn/Cd/Sb). Three parameters (LF _L , LR, EF _P ) were defined to predict different metal leaching behaviors. The leaching factor (LF _L ) of metals was 10-60 for Pb/Sb/Cd/Co/Cu and decreased to 1-2 for Ni/Cr/Mg/Al/Fe. Metals showed a divergent extent of lung retention (LR), including high retention (LR>10, Al/Cd/Cr/Ba/Ni/Ti/Sn/V/Sb), moderate retention (2 <LR<10, Pb/Mn/Fe), minor retention (1 < LR <2, Cu/Co), and negligible retention (LR<1, Ca/Mg/Zn). V and Ti were found to be mainly from indoor PM sources and deserve a close attention in healthy individuals. C-, Al- and Ti-rich fine particles were the most common pulmonary particles imaged by spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM). These data establish a foundation for classification and further risk assessment of the metal species in pulmonary PM.
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