Reply to A. Kurreck et al and M.S. Copur et al.

Competing Interests: Richard AdamsHonoraria: Merck Serono, Servier, AmgenConsulting or Advisory Role: Merck Serono, Amgen, Servier, BayerSpeakers' Bureau: Merck SeronoResearch Funding: AstraZeneca (Inst), Merck Sharp & Dohme (Inst)Travel, Accommodations, Expenses: Servier, Amgen, Merck Serono, AstraZeneca Richard WilsonHonoraria: Servier, Amgen, Bristol Myers SquibbConsulting or Advisory Role: Amgen, CV6 Therapeutics, Pierre Fabre, Amphista Therapeutics (Inst), NuCana (Inst)Travel, Accommodations, Expenses: Amgen, Pierre Fabre Louise BrownResearch Funding: AstraZeneca (Inst) Tim MaughanEmployment: AstraZenecaConsulting or Advisory Role: Vertex, Pierre FabreResearch Funding: AstraZeneca (Inst), PsiOxus Therapeutics (Inst), Merck KGaA (Inst), Almac Diagnostics (Inst)Patents, Royalties, Other Intellectual Property: patent pendingNo other potential conflicts of interest were reported.